PL EN
Dopamine D2 receptor partial agonists in the treatment of schizophrenia -example of brexpiprazole
 
More details
Hide details
1
Uniwersytet Medyczny w Łodzi
 
 
Submission date: 2023-08-24
 
 
Final revision date: 2023-10-26
 
 
Acceptance date: 2023-10-27
 
 
Online publication date: 2024-08-31
 
 
Publication date: 2024-08-31
 
 
Corresponding author
Katarzyna Maria Bliźniewska-Kowalska   

Uniwersytet Medyczny w Łodzi
 
 
Psychiatr Pol 2024;58(4):581-593
 
KEYWORDS
TOPICS
ABSTRACT
Since the 1950s, there have been rapid developments in psychiatric pharmacotherapy, resulting not only in more effective treatment of patients, but also in improvements in minimizing adverse effects of therapy. Modern third-generation antipsychotics, in addition to antagonism toward D2 receptors, also exhibit partial agonism toward dopamine receptors. Such a mechanism of action is intended to regulate dopaminergic transmission – inhibit (antagonism) it in pathways where it is excessive (excessive transmission in the mesolimbic pathway in psychotic patients, excessive transmission in the tuberoinfundibular pathway in patients with hyperprolactinemia) and stimulate (agonism) it in pathways where it is too low (mesocortical pathway). This has a beneficial effect on both the reduction of adverse symptoms and the negative, affective and cognitive symptoms of patients suffering from schizophrenia. The purpose of this review article is to present the most important clinical aspects of the use of dopamine D2 receptor partial agonists in the treatment of schizophrenia, using brexpiprazole as an example, and to define the profile of patients to whom this drug could be dedicated – based on recent studies.
eISSN:2391-5854
ISSN:0033-2674
Journals System - logo
Scroll to top