ARTICLE
An interaction between a polymorphism of the serotonin transporter (5HTT) gene and the clinical picture of adolescents with combined type of ADHD (hyperkinetic disorder) and youth drinking.
1
Pomorski Uniwersytet Medyczny w Szczecinie
2
Uniwersytet Szczeciński
3
Pomorski Uniwersytet Medyczny
Submission date: 2013-06-12
Final revision date: 2013-11-08
Acceptance date: 2013-11-08
Publication date: 2014-06-28
Corresponding author
Izabela Ewa Gorzkowska
Pomorski Uniwersytet Medyczny w Szczecinie, Broniewskiego 26, 71-460 Szczecin, Polska
Pomorski Uniwersytet Medyczny w Szczecinie, Broniewskiego 26, 71-460 Szczecin, Polska
Psychiatr Pol 2014;48(3):541–551
KEYWORDS
TOPICS
ABSTRACT
Objectives:
Introduction. The combined type of ADHD and alcohol dependence are two different disorders. Research demonstrates that 45-55% of patients diagnosed with ADHD also suffer from comorbid substance abuse, and 11-55% of patients diagnosed with substance abuse suffer from undiagnosed ADHD. Alcohol is by far the most widely used psychoactive substance in the European culture. The serotonin transporter (5HHT) gene has been implicated as one of the candidate genes in both disorders in recent molecular genetic research. Aim of study. The aim of the present study was to seek a common clinical and biological marker for hyperkinetic disorder and youth drinking.
Methods:
Methods. The study was conducted at the Department of Psychiatry, Pomeranian Medical University, Szczecin (Poland) between 2008 and 2012. The sample consisted of 100 combined type ADHD patients, 51 adolescents youth drinking and 100 individuals without mental disorders or addiction in a population-based group. The 5HHT gene polymorphism was examined using PCR (Polymerase Chain Reaction).
Results:
Results. A preferential trend for the “s” short allele of the investigated 5HHT gene polymorphism was observed in all the groups of adolescents compared to the population-based group of adults without alcohol dependence (p=0.01).
Conclusions:
Conclusions: Based on the conducted study a provisional conclusion may be drawn that the presence of the short “s” allele of the 5HHT gene polymorphism may be a prognostic factor of impulsivity in ADHD and of predisposition to alcohol dependence.
Introduction. The combined type of ADHD and alcohol dependence are two different disorders. Research demonstrates that 45-55% of patients diagnosed with ADHD also suffer from comorbid substance abuse, and 11-55% of patients diagnosed with substance abuse suffer from undiagnosed ADHD. Alcohol is by far the most widely used psychoactive substance in the European culture. The serotonin transporter (5HHT) gene has been implicated as one of the candidate genes in both disorders in recent molecular genetic research. Aim of study. The aim of the present study was to seek a common clinical and biological marker for hyperkinetic disorder and youth drinking.
Methods:
Methods. The study was conducted at the Department of Psychiatry, Pomeranian Medical University, Szczecin (Poland) between 2008 and 2012. The sample consisted of 100 combined type ADHD patients, 51 adolescents youth drinking and 100 individuals without mental disorders or addiction in a population-based group. The 5HHT gene polymorphism was examined using PCR (Polymerase Chain Reaction).
Results:
Results. A preferential trend for the “s” short allele of the investigated 5HHT gene polymorphism was observed in all the groups of adolescents compared to the population-based group of adults without alcohol dependence (p=0.01).
Conclusions:
Conclusions: Based on the conducted study a provisional conclusion may be drawn that the presence of the short “s” allele of the 5HHT gene polymorphism may be a prognostic factor of impulsivity in ADHD and of predisposition to alcohol dependence.
Project no. RCN/SN/0610/2021/1 implemented from 2022 to 2024
Total value of the project: PLN 490 000
Amount funded by the MEiN: PLN 100 000
Aims of the project: Publication in Open Access mode on the Internet of English and Polish language versions of 12 consecutive issues of the journal Psychiatria Polska (years 2022-2024). Modernization and redesign of the journal’s website. Financing of the Editorial System. Copy editing and proofreading of journal issues. Counteracting scientific misinformation. Submission of electronic versions of the journal to the National Digital Library Polona and the Digital Library of Scientific Publications Academica.
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