ANKK1 gene in psychiatry
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Psychiatr Pol 2011;45(3):349-356
According to last findings, one of the most commonly studied polymorphisms in psychiatry-Taq1A is located in the ANNK1(Ankyrin Repeat and Kinase Domain containing 1) gene, not in the dopamine receptor 2 (DRD2) gene. This polymorphism has been extensively studied in relation to alcohol, nicotine and drugs addiction, eating disorders, ADHD, schizophrenia and pharmacogenetics. The ANKK1 gene contains single serine/threonine kinase domain and 11 anIcyrin repeats. ANKK1 belongs to RIP (Receptor-Interacting Protein) serine/threonine kinase family. These kinases are important in cell proliferation, differentiation and activate transcription factors. DRD2 gene is probably regulated by ANKK1 through NF-kappa B (Nuclear Factor-kappaB). ANKK1 is activated by apomorphine- dopaminergic agonist, which indicates another link with the dopaminergic system. It seems accurate to search for associations of polymorphisms in ANKK1 gene with dopaminergic system disorders.
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