Family-based association study of dopaminergic genes polymorphisms and EAS temperamental traits
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Psychiatr Pol 2013;47(2):185-195
Aim. The aim of the present study was to identify relations between several polymorphisms in dopamine genes (DRD2, DRD3, DRD4, SNAP-25, ANKK1 and DAT1) and temperamental traits distinguished in the EAS theory. In this study the family-based method was used. Method. The study was run on 149 biological families with one or two children aged 3-12. Temperamental data were obtained using Buss and Plomin EAS-C Temperament Questionnaire. Results. Significant associations between two SNPs in the SNAP-25 gene (rs363039 and rs363050) and shyness was found. Significant relationships of this trait with haplotypes in DAT1 and SNAP-25 genes was also identified. Conclusion. The data collected suggest that variability in dopamine genes may have impact on the development of temperamental shyness, which is recognized as a fear of strangers.
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