Family-based association study of dopaminergic genes polymorphisms and EAS temperamental traits

Aim. The aim of the present study was to identify relations between several polymorphisms in dopamine genes (DRD2, DRD3, DRD4, SNAP-25, ANKK1 and DAT1) and temperamental traits distinguished in the EAS theory. In this study the family-based method was used. Method. The study was run on 149 biological families with one or two children aged 3-12. Temperamental data were obtained using Buss and Plomin EAS-C Temperament Questionnaire. Results. Significant associations between two SNPs in the SNAP-25 gene (rs363039 and rs363050) and shyness was found. Significant relationships of this trait with haplotypes in DAT1 and SNAP-25 genes was also identified. Conclusion. The data collected suggest that variability in dopamine genes may have impact on the development of temperamental shyness, which is recognized as a fear of strangers.

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eISSN:	2391-5854
ISSN:	0033-2674

The journal is supported by the State Treasury as part of the Development of Scientific Journals (RCN) program
Project no. RCN/SN/0610/2021/1 implemented from 2022 to 2024
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