ARTICLE
Family association study of Transforming Growth Factor Beta1 gene polymorphisms in schizophrenia
| 1 | Zakład Genetyki w Psychiatrii Katedry Psychiatrii UM w Poznaniu |
| 2 | Klinika Psychiatrii Dorosłych UM w Poznaniu |
| 3 | Pharmacogenetics Research Clinic, Campbell Family Mental Health Research, Institute Centre for Addiction and Mental Health, Toronto, Canada |
CORRESPONDING AUTHOR
Paweł Kapelski
Zakład Genetyki w Psychiatrii Katedry Psychiatrii UM w Poznaniu, ul. Szpitalna 27/33, 60-572 Poznań, Polska
Zakład Genetyki w Psychiatrii Katedry Psychiatrii UM w Poznaniu, ul. Szpitalna 27/33, 60-572 Poznań, Polska
Submission date: 2015-10-20
Final revision date: 2015-12-14
Acceptance date: 2016-01-06
Publication date: 2016-08-30
Psychiatr Pol 2016;50(4):761–770
KEYWORDS
TOPICS
ABSTRACT
Objectives:
Schizophrenia is a serious mental illness with chronic symptoms and significant impairment in psychosocial functioning. An etiopathological role for immunologic abnormalities in schizophrenia was hypothesized. Inflammatory markers are well-known etiological factors for psychiatric disorders, including schizophrenia. Several studies have investigated the possible effects of antipsychotics on inflammation and neurogenesis. Additionally, antiinflammatory adjuvant therapy has been under investigation as a treatment option for schizophrenia. Transforming Growth Factor Beta 1 (TGFB1) signaling is critical for many biological processes, including proliferation, development, differentiation and regeneration. Multiple members of the TGFB1 superfamily play a role in the developing nervous system and are regulated by neuronal activity. We conducted family-based study to assess whether TGFB1 gene is associated with susceptibility to schizophrenia in Polish population.
Methods:
Two functional polymorphisms: rs1800469 (C-509T) and rs1800470 (T869C) of TGFB1 gene were analyzed within a group of 147 trios (patients diagnosed with schizophrenia and their healthy parents) using Transmission Disequilibrium Test (TDT).
Results:
No association of these polymorphisms with schizophrenia was found in Polish population.
Conclusions:
Further studies on larger groups along with correlation with circulating protein levels are needed.
Schizophrenia is a serious mental illness with chronic symptoms and significant impairment in psychosocial functioning. An etiopathological role for immunologic abnormalities in schizophrenia was hypothesized. Inflammatory markers are well-known etiological factors for psychiatric disorders, including schizophrenia. Several studies have investigated the possible effects of antipsychotics on inflammation and neurogenesis. Additionally, antiinflammatory adjuvant therapy has been under investigation as a treatment option for schizophrenia. Transforming Growth Factor Beta 1 (TGFB1) signaling is critical for many biological processes, including proliferation, development, differentiation and regeneration. Multiple members of the TGFB1 superfamily play a role in the developing nervous system and are regulated by neuronal activity. We conducted family-based study to assess whether TGFB1 gene is associated with susceptibility to schizophrenia in Polish population.
Methods:
Two functional polymorphisms: rs1800469 (C-509T) and rs1800470 (T869C) of TGFB1 gene were analyzed within a group of 147 trios (patients diagnosed with schizophrenia and their healthy parents) using Transmission Disequilibrium Test (TDT).
Results:
No association of these polymorphisms with schizophrenia was found in Polish population.
Conclusions:
Further studies on larger groups along with correlation with circulating protein levels are needed.
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