Inflammatory theory of depression
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Klinika Psychiatrii Dorosłych, Uniwersytet Medyczny w Łodzi
Submission date: 2017-04-27
Final revision date: 2017-07-10
Acceptance date: 2017-09-06
Online publication date: 2018-06-30
Publication date: 2018-06-30
Corresponding author
Monika Talarowska   

Klinika Psychiatrii Dorosłych, Uniwersytet Medyczny w Łodzi, Aleksandrowska 159, 91-229 Łódź, Polska
Psychiatr Pol 2018;52(3):437-447
Brain diseases are one of the most socially and economically burdening diseases in Europe. Among all brain diseases, more than 60% of social and economic costs are generated by mental disorders (mainly depressive disorders and anxiety disorders). Recurrent depressive disorders have been a significant civilizational problem in recent times. Among the biological and psychological theories explaining the causes of depression, the hypothesis involving an active inflammatory process taking place in a human organism is becoming increasingly important. The following are considered inflammation markers: inflammatory enzymes (e.g., manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), inducible nitric oxide synthase), proinflammatory and anti-inflammatory cytokines, and the phenomenon of oxidative stress. Through the kynurenine pathway, these factors lead to a deficit in serotonin and melatonin, which is considered one of the main reasons of depression. We can consider depression to be a chronic cold of the organism, which develops in response to the action of greater or smaller everyday stressors. This paper presents results of recent studies regarding this matter.
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