Misuse and abuse of quetiapine
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Klinika Psychiatrii Dzieci i Młodzieży IPiN w Warszawie
Kierownik: dr n. med. B. Habrat, Zespół Profilaktyki i Leczenia Uzależnień IPiN w Warszawie
kierownik prof.dr hab. P. Bieńkowski, Zakład Farmakologii i Fizjologii Układu Nerwowego IPiN w Warszawie
Submission date: 2014-06-05
Final revision date: 2014-10-09
Acceptance date: 2014-10-23
Publication date: 2015-02-24
Corresponding author
Agnieszka Piróg-Balcerzak   

Klinika Psychiatrii Dzieci i Młodzieży IPiN w Warszawie, sobieskiego 1/9, 02-957 warszawa, Polska
Psychiatr Pol 2015;49(1):81-93
Quetiapine is an atypical antipsychotic agent, frequently used in psychiatry, often for symptomatic treatment against a number of mental disorders differing from the registration indications. One of the use is to soothe the clinical conditions caused by the use of various psychoactive substances. The paper presents and discusses the reports of quetiapine misuse, abuse, and even mental addiction, as well as symptoms similar to the so-called discontinuation syndrome, often mixed with withdrawal syndrome occurring in the course of addiction. Most reports concern males, and especially those with a history of other psychoactive substance abuse, and personality disorders, often in conflict with the law. Therefore, clinicians should be cautious when prescribing quetiapine to such patients. The article discusses potential mechanisms responsible for quetiapine abuse. This is probably related to its sedative and anxiolytic activity which results in the frequent use with stimulants. Also, high affinity for the H1 receptor, as antihistamines agents causes rewarding action.
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