Semantic decisions in adolescents with autism spectrum disorders - functional magnetic resonance imaging study
1
Warszawski Uniwersytet Medyczny, Klinika Wieku Rozwojowego
2
Instytut Fizjologii i Patologii Słuchu
Submission date: 2020-10-26
Final revision date: 2021-01-24
Acceptance date: 2021-02-02
Online publication date: 2022-10-31
Publication date: 2022-10-31
Psychiatr Pol 2022;56(5):1079–1092
KEYWORDS
TOPICS
ABSTRACT
Objectives:
Goal: to assess fMRI activation during semantic tasks in adolescents with ASD.
Methods:
Material: 44 right-handed male adolescents aged 12-19 (mean 14.3 ± 2.0) - 31 with autism spectrum disorders who met DSM-IV-TR criteria for Asperger's syndrome and 13 neurotypical adolescents matched according to age and handiness. Method: Functional testing (fMRI) was performed during semantic decisions tasks and phonological decisions in three categories of tasks: concrete nouns, verbs with plural meanings, words describing states of mind, as a control condition. Statistical analyzes were performed at the level of p <0.05 with FWE (family-wise error) correction and p <0.001.
Results:
Results: lower BOLD signal was demonstrated in many brain areas including precuneus, posterior cingulate gyrus, angular gyrus, parahippocampal gyrus, regardless of task category and processing method in the ASD group. The smallest differences in semantic processing were found for concrete nouns and the greatest ones for words describing states of mind.
Conclusions:
Conclusions: the presence of different activation patterns in the ASD group suggests that far more than just the areas traditionally attributed to language processing, are involved in semantic deficits in ASD.
Goal: to assess fMRI activation during semantic tasks in adolescents with ASD.
Methods:
Material: 44 right-handed male adolescents aged 12-19 (mean 14.3 ± 2.0) - 31 with autism spectrum disorders who met DSM-IV-TR criteria for Asperger's syndrome and 13 neurotypical adolescents matched according to age and handiness. Method: Functional testing (fMRI) was performed during semantic decisions tasks and phonological decisions in three categories of tasks: concrete nouns, verbs with plural meanings, words describing states of mind, as a control condition. Statistical analyzes were performed at the level of p <0.05 with FWE (family-wise error) correction and p <0.001.
Results:
Results: lower BOLD signal was demonstrated in many brain areas including precuneus, posterior cingulate gyrus, angular gyrus, parahippocampal gyrus, regardless of task category and processing method in the ASD group. The smallest differences in semantic processing were found for concrete nouns and the greatest ones for words describing states of mind.
Conclusions:
Conclusions: the presence of different activation patterns in the ASD group suggests that far more than just the areas traditionally attributed to language processing, are involved in semantic deficits in ASD.
Project no. RCN/SN/0610/2021/1 implemented from 2022 to 2024
Total value of the project: PLN 490 000
Amount funded by the MEiN: PLN 100 000
Aims of the project: Publication in Open Access mode on the Internet of English and Polish language versions of 12 consecutive issues of the journal Psychiatria Polska (years 2022-2024). Modernization and redesign of the journal’s website. Financing of the Editorial System. Copy editing and proofreading of journal issues. Counteracting scientific misinformation. Submission of electronic versions of the journal to the National Digital Library Polona and the Digital Library of Scientific Publications Academica.
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