ARTICLE
The serum magnesium concentration as a potential state marker in patients with unipolar affective disorder
Gabriel Nowak
2,4
| 1 | Zakład Zaburzeń Afektywnych Katedry Psychiatrii UJ CM |
| 2 | Pracownia Neurobiologii Pierwiastków Śladowych Instytutu Farmakologii PAN w Krakowie |
| 3 | Katedra Chemii Analitycznej, Akademia Górniczo-Hutnicza, ul. Mickiewicza 30, 30-059 Kraków; |
| 4 | Katedra Farmakobiologii UJ CM |
| 5 | Zakład Epidemiologii i Badań Populacyjnych Instytutu Zdrowia Publicznego UJ CM |
| 6 | Katedra Chemii Nieorganicznej i Analitycznej UJ CM |
CORRESPONDING AUTHOR
Krzysztof Styczeń
Zakład Zaburzeń Afektywnych, Katedra Psychiatrii UJ CM, ul. Kopernika 21a, 31-501 Kraków, ul. Kopernika 21 A, 31-501 Kraków, Polska
Zakład Zaburzeń Afektywnych, Katedra Psychiatrii UJ CM, ul. Kopernika 21a, 31-501 Kraków, ul. Kopernika 21 A, 31-501 Kraków, Polska
Submission date: 2015-04-21
Final revision date: 2015-05-18
Acceptance date: 2015-05-20
Publication date: 2015-12-31
Psychiatr Pol 2015;49(6):1265–1276
KEYWORDS
TOPICS
ABSTRACT
Objectives:
The growing body of evidence suggests that magnesium levels can serve as a marker of major depressive disorder (MDD), but findings from clinical trials remain inconclusive. The aim of the presented study was to determine the magnesium concentration in serum of patients with MDD (in the active stage of the disease or in remission) and to analyze the role of magnesium levels as apotential marker of the disease.
Methods:
Sixty-nine patients with current depressive episode, 45 patients in remission and 50 healthy volunteers were enrolled into the case-control study. The magnesium concentration was measured by flame atomic absorption spectrometry (FAAS).
Results:
The mean serum magnesium concentration of patients in the depressed phase was significantly higher, compared to the control group. Moreover, magnesium levels of patients in the remission were not significantly different from the concentrations recorded in the healthy volunteers. There was also a positive correlation between the magnesium levels and the severity of depression measured by the Hamilton Rating Scale for Depression (HDRS) and the Montgomery-Asberg Depression Rating Scale (MADRS).
Conclusions:
The obtained results may suggest a role of magnesium as a state marker reflecting the pathophysiological changes underlying MDD and accompanying severe depressive episodes.
The growing body of evidence suggests that magnesium levels can serve as a marker of major depressive disorder (MDD), but findings from clinical trials remain inconclusive. The aim of the presented study was to determine the magnesium concentration in serum of patients with MDD (in the active stage of the disease or in remission) and to analyze the role of magnesium levels as apotential marker of the disease.
Methods:
Sixty-nine patients with current depressive episode, 45 patients in remission and 50 healthy volunteers were enrolled into the case-control study. The magnesium concentration was measured by flame atomic absorption spectrometry (FAAS).
Results:
The mean serum magnesium concentration of patients in the depressed phase was significantly higher, compared to the control group. Moreover, magnesium levels of patients in the remission were not significantly different from the concentrations recorded in the healthy volunteers. There was also a positive correlation between the magnesium levels and the severity of depression measured by the Hamilton Rating Scale for Depression (HDRS) and the Montgomery-Asberg Depression Rating Scale (MADRS).
Conclusions:
The obtained results may suggest a role of magnesium as a state marker reflecting the pathophysiological changes underlying MDD and accompanying severe depressive episodes.
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