Vitamin D deficiency and depressive symptoms: meta-analysis of studies .
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1
Śląski Uniwersytet Medyczny w Katowicach, Katedra Psychiatrii i Psychoterapii, Oddział Kliniczny Psychiatrii i Psychoterapii Wieku Rozwojowego
2
Centrum Pediatrii im. Jana Pawła II w Sosnowcu
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Akademia Koźmińskiego, Warszawa
Submission date: 2020-06-16
Final revision date: 2020-10-24
Acceptance date: 2020-11-29
Online publication date: 2022-12-31
Publication date: 2022-12-31
Corresponding author
Krzysztof Maria Wilczyński
Oddział Kliniczny Psychiatrii i Psychoterapii Wieku Rozwojowego, Katedra Psychiatrii i Psychoterapii, Śląski Uniwersytet Medyczny w Katowicach
Centrum Pediatrii im. Jana Pawła II w Sosnowcu
Psychiatr Pol 2022;56(6):1327-1344
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ABSTRACT
Aim:
The aim of this study was the identification and summary of studies examining the relationship between vitamin D levels and the risk of depression and depressive symptoms severity, published between January 2008 and January 2019.
Material and Methods:
A systematic review of literature published within the last 10 years and accessible in PubMed database was conducted by each author separately based on predetermined inclusion criteria.
Results:
Out of the 823 studies qualified to the initial abstract analysis, 24 were included into the full-text review and 18 into the meta-analysis. Statistically significant odds ratio was obtained for risk of depression in the course of vitamin D deficiency (OR = 1.51; 95% CI: 1.4–1.62; p < 0.01).
Conclusions:
The analysis of available literature seems to indicate that there is an association between risk of depression and vitamin D deficiency. However, current literature does not give the possibility to state explicitly what is the exact mechanism and direction of this dependency