ARTICLE
Increased plasma pro-inflammatory cytokine concentrations after myocardial infarction and the presence of depression during next 6-months.
1
Clinic of Psychiatric Disorders and Neuroses, Medical University of Gdansk
2
Department of Clinical Immunology and Transplantation, Medical University of Gdansk
3
1st Department of Cardiology, Medical University of Gdansk
Submission date: 2014-07-10
Final revision date: 2014-10-02
Acceptance date: 2014-10-28
Publication date: 2015-06-30
Corresponding author
Psychiatr Pol 2015;49(3):455–464
KEYWORDS
TOPICS
ABSTRACT
Objectives:
The aim of this study was to investigate plasma concentrations of four pro-inflammatory cytokines (IL17a, IL6, TNFα and IL12p70) in patients with myocardial infarction and to analyse them according to presence of depression observed during first 6 months after myocardial infarction.
Methods:
In 44 patients with the first acute STEMI (ST segment elevation myocardial infarction) plasma levels of IL17a, IL6, TNFα and IL12p70 were measured on the 3rd and 5th day after the MI. Cytokine concentrations were analyzed according to the presence of depression during 6 months of observation.
Results:
Two groups of patients distinguished according to presence of depression during 6 months of observation differed in their inflammatory reaction to MI. In the depression group all four cytokines on the 3rd day after the MI were elevated compared to control and on the 5th day two of them: IL17a and IL6 were still elevated. In the group without depression on the 3rd day only two of four investigated cytokines were elevated and on the 5th day only IL6 concentration remained higher.
Conclusions:
It can be assumed that more pronounced inflammatory response as an element of stress reaction after MI can predispose to depression. IL17a increase can play particularly important role in this process.
The aim of this study was to investigate plasma concentrations of four pro-inflammatory cytokines (IL17a, IL6, TNFα and IL12p70) in patients with myocardial infarction and to analyse them according to presence of depression observed during first 6 months after myocardial infarction.
Methods:
In 44 patients with the first acute STEMI (ST segment elevation myocardial infarction) plasma levels of IL17a, IL6, TNFα and IL12p70 were measured on the 3rd and 5th day after the MI. Cytokine concentrations were analyzed according to the presence of depression during 6 months of observation.
Results:
Two groups of patients distinguished according to presence of depression during 6 months of observation differed in their inflammatory reaction to MI. In the depression group all four cytokines on the 3rd day after the MI were elevated compared to control and on the 5th day two of them: IL17a and IL6 were still elevated. In the group without depression on the 3rd day only two of four investigated cytokines were elevated and on the 5th day only IL6 concentration remained higher.
Conclusions:
It can be assumed that more pronounced inflammatory response as an element of stress reaction after MI can predispose to depression. IL17a increase can play particularly important role in this process.
Project no. RCN/SN/0610/2021/1 implemented from 2022 to 2024
Total value of the project: PLN 490 000
Amount funded by the MEiN: PLN 100 000
Aims of the project: Publication in Open Access mode on the Internet of English and Polish language versions of 12 consecutive issues of the journal Psychiatria Polska (years 2022-2024). Modernization and redesign of the journal’s website. Financing of the Editorial System. Copy editing and proofreading of journal issues. Counteracting scientific misinformation. Submission of electronic versions of the journal to the National Digital Library Polona and the Digital Library of Scientific Publications Academica.
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