ARTICLE
Internal capsule integrity and its sex-related structural differences in early-onset schizophrenia - diffusion tensor imaging study.
| 1 | II Klinika Psychiatrii UW; Oddział Kliniczny Psychiatrii, Uniwersytet Medyczny w Łodzi |
| 2 | II Klinika Psychiatrii, Uniwersytet Medyczny w Łodzi |
| 3 | Scanlab, Diagnostyka Medyczna Księży Młyn |
| 4 | Katedra Socjologii Organizacji i Zarządzania, Uniwersytet Łódzki |
CORRESPONDING AUTHOR
Marta Gawłowska
II Klinika Psychiatrii UW; Oddział Kliniczny Psychiatrii, Uniwersytet Medyczny w Łodzi, ul. Czechosłowacka 8/10, 92-216 Łódź, Polska
II Klinika Psychiatrii UW; Oddział Kliniczny Psychiatrii, Uniwersytet Medyczny w Łodzi, ul. Czechosłowacka 8/10, 92-216 Łódź, Polska
Submission date: 2014-01-23
Final revision date: 2014-03-10
Acceptance date: 2014-04-03
Publication date: 2015-04-30
Psychiatr Pol 2015;49(2):349–361
KEYWORDS
TOPICS
ABSTRACT
Objectives:
In schizophrenia, the most repeatable DTI findings concern reduced FA in temporal and frontal lobes with associated abnormalities in connecting neural fibers. The goal of study was to evaluate the differences in FA of the internal capsule in EOS-patients and healthy controls and to place emphasis on the sex as a potential factor determining a predominant pathological pattern of described changes.
Methods:
30 EOS patients and 30 healthy controls were studied using DTI. FA measures within internal capsules were performed in selected ROIs. For statistical analyses the one-way ANOVA test was used (p<0.05).
Results:
Significant differences of FA between EOS-patients and controls in the right ALIC with lower values of FA in EOS were observed. Within the women sub-groups, statistical differences of FA were observed only for the right ALIC. There were no statistically significant differences within men sub-groups.
Conclusions:
1. Statistically significant differences were found between EOS – subjects (subgroups of woman only) and the control group within the WM diffusivity of the brain in the right ALIC. 2. These results indicate possible involvement of the structures of internal capsule in the EOS development.
In schizophrenia, the most repeatable DTI findings concern reduced FA in temporal and frontal lobes with associated abnormalities in connecting neural fibers. The goal of study was to evaluate the differences in FA of the internal capsule in EOS-patients and healthy controls and to place emphasis on the sex as a potential factor determining a predominant pathological pattern of described changes.
Methods:
30 EOS patients and 30 healthy controls were studied using DTI. FA measures within internal capsules were performed in selected ROIs. For statistical analyses the one-way ANOVA test was used (p<0.05).
Results:
Significant differences of FA between EOS-patients and controls in the right ALIC with lower values of FA in EOS were observed. Within the women sub-groups, statistical differences of FA were observed only for the right ALIC. There were no statistically significant differences within men sub-groups.
Conclusions:
1. Statistically significant differences were found between EOS – subjects (subgroups of woman only) and the control group within the WM diffusivity of the brain in the right ALIC. 2. These results indicate possible involvement of the structures of internal capsule in the EOS development.
RELATED ARTICLE
Project no. RCN/SN/0610/2021/1 implemented from 2022 to 2024
Total value of the project: PLN 490 000
Amount funded by the MEiN: PLN 100 000
Aims of the project: Publication in Open Access mode on the Internet of English and Polish language versions of 12 consecutive issues of the journal Psychiatria Polska (years 2022-2024). Modernization and redesign of the journal’s website. Financing of the Editorial System. Copy editing and proofreading of journal issues. Counteracting scientific misinformation. Submission of electronic versions of the journal to the National Digital Library Polona and the Digital Library of Scientific Publications Academica.
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