Psychiatric disturbances in five patients with MELAS syndrome
| 1 | Kierownik: prof. dr n. med. J. Zeman, Katedra Medycyny Dzieci i Młodzieży, Pierwszy Wydział Medycyny Uniwersytetu Karola w Pradze |
| 2 | Kierownik: prof. dr n. med. J. Raboch, Katedra Psychiatrii, Pierwszy Wydział Medycyny Uniwersytetu Karola w Pradze |
CORRESPONDING AUTHOR
Jiri Zeman
Kierownik: prof. dr n. med. J. Zeman, Katedra Medycyny Dzieci i Młodzieży, Pierwszy Wydział Medycyny Uniwersytetu Karola w Pradze, Ke Karlovu 2, 120 00 Prague 2, Czech Republic
Kierownik: prof. dr n. med. J. Zeman, Katedra Medycyny Dzieci i Młodzieży, Pierwszy Wydział Medycyny Uniwersytetu Karola w Pradze, Ke Karlovu 2, 120 00 Prague 2, Czech Republic
Submission date: 2014-01-13
Final revision date: 2014-03-06
Acceptance date: 2014-03-08
Publication date: 2014-10-31
Psychiatr Pol 2014;48(5):1035–1045
KEYWORDS
TOPICS
ABSTRACT
Objectives:
Mitochondrial disorders of energetic metabolism (MD) represent a heterogeneous group of diseases manifesting at any age with a broad spectrum of clinical symptoms, including psychiatric disorders.
Methods:
The aim of the study was to characterize psychiatric symptoms and diagnoses in five patients with MELAS syndrome between the ages of 17 and 53 year.
Results:
Four of MELAS patients them harbored the prevalent mitochondrial DNA (mtDNA) mutation 3243A>G, and one patient had the mtDNA mutation 12706T>C. Three patients had positive family histories for MELAS syndrome. In one patient, depression was diagnosed as the first symptom of MELAS syndrome. Depression also preceded a stroke-like episode in one patient. Four patients had disturbed cognitive functions, confusional states occurred in three patients. One patient manifested psychotic (schizophrenia-like) symptom.
Conclusions:
Mitochondrial disorders deserve consideration as part of the differential diagnosis, especially if there is suspected involvement of other organ groups or positive family history of MD.
Mitochondrial disorders of energetic metabolism (MD) represent a heterogeneous group of diseases manifesting at any age with a broad spectrum of clinical symptoms, including psychiatric disorders.
Methods:
The aim of the study was to characterize psychiatric symptoms and diagnoses in five patients with MELAS syndrome between the ages of 17 and 53 year.
Results:
Four of MELAS patients them harbored the prevalent mitochondrial DNA (mtDNA) mutation 3243A>G, and one patient had the mtDNA mutation 12706T>C. Three patients had positive family histories for MELAS syndrome. In one patient, depression was diagnosed as the first symptom of MELAS syndrome. Depression also preceded a stroke-like episode in one patient. Four patients had disturbed cognitive functions, confusional states occurred in three patients. One patient manifested psychotic (schizophrenia-like) symptom.
Conclusions:
Mitochondrial disorders deserve consideration as part of the differential diagnosis, especially if there is suspected involvement of other organ groups or positive family history of MD.
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