Can microbiology affect psychiatry? A link between gut microbiota and psychiatric disorders
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Zakład Angiologii Uniwersytetu Medycznego w Łodzi
Zakład Anatomii Prawidłowej i Klinicznej Uniwersytetu Medycznego w Łodzi
Klinika Zaburzeń Afektywnych i Psychotycznych Uniwersytetu Medycznego w Łodzi
Submission date: 2017-07-18
Final revision date: 2017-11-16
Acceptance date: 2017-12-10
Online publication date: 2018-12-29
Publication date: 2018-12-29
Corresponding author
Michał Polguj   

Zakład Angiologii Uniwersytetu Medycznego w Łodzi, ul. Narutowicza 60, 90-136 Łódź, Narutowicza 60, 90-136 Łódź, Polska
Psychiatr Pol 2018;52(6):1023-1039
Every single human consists of thousands of genes, billions of neurons and trillions of bacteria. There is a rapidly growing number of data that links the gut microbiome to the development and functioning of the central nervous system, which is a currently proposed paradigm shift in neuroscience. Knowledge on the relationship between gut microbiota and mental disorders is constantly increasing. This phenomenon is known as “gut-brain axis”. The strongest evidence for the role of microbes in the gut-brain axis comes from animal studies. Nevertheless, the gutbrain crosstalk is a bidirectional communication system that not only provides gastrointestinal homeostasis, but can also affect motivation as well as higher cognitive functions. Moreover, gut microbiome can be associated with obesity and inflammatory gastrointestinal disorders. According to the recent studies, there is a link between the composition of gut microbiota and mental disorders in animals (response to depression and chronic stress). This subject requires further examination, especially taking into consideration potential therapeutic options.
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