Objectives:
To determine the relationship between the use of CBD, other psychoactive substances and medications, and temperament traits according to the TEMPS-A scale.

Methods:
A total of 173 individuals completed an online survey that included the TEMPS-A questionnaire and questions regarding socio-demographic characteristics, CBD use, other psychoactive substances, and medications. Statistical analysis was performed using Statistica 13. The Shapiro-Wilk test, Mann-Whitney U test, Kruskal-Wallis ANOVA, Chi2 test, and regression analysis were applied.

Results:
No significant differences in temperament traits were found between the CBD- using and non-CBD-using groups, regardless of the form in which CBD was used. The use of more than three psychoactive substances or medications was associated with greater hyperthymic and cyclothymic temperament. CBD users were more likely to smoke marijuana and cigarettes, and less likely to use non-opioid analgesics. Smoking marijuana was associated with lower levels of depressive temperament, while the use of painkillers, opioids and benzodiazepines was associated with higher levels of anxious temperament.

Conclusions:
CBD users did not differ in temperament from the control group, although correlations between the severity of temperament traits and the use of other substances and medications were observed. CBD use was associated with more frequent smoking of cigarettes and marijuana, and less frequent use of painkillers.