The effect of two predictors’ interaction on short- and long-term treatment outcomes of schizophrenia
| 1 | Zakład Psychiatrii Środowiskowej Katedry Psychiatrii CMUJ |
| 2 | Stowarzyszenie na Rzecz Rozwoju Psychiatrii i Opieki Środowiskowej |
| 3 | Zakład Psychiatrii Środowiskowej Katedry Psychiatrii CM UJ |
| 4 | Klinika Psychiatrii Dorosłych, Dzieci i Młodzieży, Szpital Uniwersytecki |
CORRESPONDING AUTHOR
Andrzej Cechnicki
Zakład Psychiatrii Środowiskowej Katedry Psychiatrii CMUJ, Pl. Sikorskiego 2/8, 31-115 Kraków, Polska
Zakład Psychiatrii Środowiskowej Katedry Psychiatrii CMUJ, Pl. Sikorskiego 2/8, 31-115 Kraków, Polska
Submission date: 2013-05-10
Final revision date: 2013-07-02
Acceptance date: 2013-07-04
Publication date: 2013-09-26
Psychiatr Pol 2013;47(5):775–786
KEYWORDS
TOPICS
ABSTRACT
Objectives:
To monitor the effect of interaction of duration of untreated psychosis (DUP) and expressed emotion (EE) on treatment outcomes in schizophrenia.
Methods:
56 individuals diagnosed with schizophrenia were assessed at 4 time points. The number of relapses, the number and duration of rehospitalizations and the severity of symptoms were assessed at index hospitalization and at 3, 7 and 12-year follow-ups.
Results:
No correlation was found between DUP and EE measured at index hospitalization. Over the 12-year period the number of rehospitalizations for individuals with short DUP and low EE did not increase, as opposed to those with short DUP and with high EE. In the group with long DUP, the number of rehospitalizations increased irrespectively of EE level. The positive syndrome in the group with short DUP and high EE was less severe than in individuals with long DUP and high EE. Analogous differences appeared in the group with low EE.
Conclusions:
1/ No correlation was found between DUP and EE at index hospitalization. 2/ Number of rehospitalizations and intensity of positive symptoms proved to be associated over time with the interaction of DUP and EE. 3/ Long-time observation and multiple assessments allow to obtain more reliable results.
To monitor the effect of interaction of duration of untreated psychosis (DUP) and expressed emotion (EE) on treatment outcomes in schizophrenia.
Methods:
56 individuals diagnosed with schizophrenia were assessed at 4 time points. The number of relapses, the number and duration of rehospitalizations and the severity of symptoms were assessed at index hospitalization and at 3, 7 and 12-year follow-ups.
Results:
No correlation was found between DUP and EE measured at index hospitalization. Over the 12-year period the number of rehospitalizations for individuals with short DUP and low EE did not increase, as opposed to those with short DUP and with high EE. In the group with long DUP, the number of rehospitalizations increased irrespectively of EE level. The positive syndrome in the group with short DUP and high EE was less severe than in individuals with long DUP and high EE. Analogous differences appeared in the group with low EE.
Conclusions:
1/ No correlation was found between DUP and EE at index hospitalization. 2/ Number of rehospitalizations and intensity of positive symptoms proved to be associated over time with the interaction of DUP and EE. 3/ Long-time observation and multiple assessments allow to obtain more reliable results.
RELATED ARTICLE
Project no. RCN/SN/0610/2021/1 implemented from 2022 to 2024
Total value of the project: PLN 490 000
Amount funded by the MEiN: PLN 100 000
Aims of the project: Publication in Open Access mode on the Internet of English and Polish language versions of 12 consecutive issues of the journal Psychiatria Polska (years 2022-2024). Modernization and redesign of the journal’s website. Financing of the Editorial System. Copy editing and proofreading of journal issues. Counteracting scientific misinformation. Submission of electronic versions of the journal to the National Digital Library Polona and the Digital Library of Scientific Publications Academica.
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