The pattern of verbal, visuospatial and procedural learning in Richardson variant of progressive supranuclear palsy in comparison to Parkinson’s disease
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Oddział Neurologii Szpitala Specjalistycznego św. Wojciecha w Gdańsku
Zakład Pielęgniarstwa Neurologiczno-Psychiatrycznego GUM
Katedra i Klinika Rehabilitacji GUM
Submission date: 2015-08-11
Final revision date: 2016-01-23
Acceptance date: 2016-04-22
Online publication date: 2017-08-29
Publication date: 2017-08-29
Corresponding author
Emilia J. Sitek   

Gdański Uniwersytet Medyczny, Zakład Pielęgniastwa Neurologiczno-Psychiatrycznego; Copernicus Sp. z o.o., Szpital Św. Wojciecha, O. Neurologii, Al. Jana Pawła II 50, 80-462 Gdańsk, Polska
Psychiatr Pol 2017;51(4):647–659
Progressive supranuclear palsy (PSP) is regarded either within spectrum of atypical parkinsonian syndromes or frontotemporal lobar degeneration. We compared the verbal, visuospatial and procedural learning profiles in patients with PSP and Parkinson’s disease (PD). Furthermore, the relationship between executive factors (initiation and inhibition) and learning outcomes was analyzed.

Thirty-three patients with the clinical diagnosis of PSP-Richardson’s syndrome (PSP-RS), 39 patients with PD and 29 age –and education –matched controls were administered Mini-Mental State Examination (MMSE), phonemic and semantic fluency tasks, Auditory Verbal Learning Test (AVLT), Visual Learning and Memory Test for Neuropsychological Assessment by Lamberti and Weidlich (Diagnosticum für Cerebralschädigung, DCS), Tower of Toronto (ToT) and two motor sequencing tasks. Patients with PSP-RS and PD were matched in terms of MMSE scores and mood.

Performance on DCS was lower in PSP-RS than in PD. AVLT delayed recall was better in PSP-RS than PD. Motor sequencing task did not differentiate between patients. Scores on AVLT correlated positively with phonemic fluency scores in both PSP-RS and PD. ToT rule violation scores were negatively associated with DCS performance in PSP-RS and PD as well as with AVLT performance in PD.

Global memory performance is relatively similar in PSP-RS and PD. Executive factors (initiation and inhibition) are closely related to memory performance in PSP-RS and PD. Visuospatial learning impairment in PSP-RS is possibly linked to impulsivity and failure to inhibit automatic responses.